Doxycycline Hyclate Vs Monohydrate

Doxycycline is a broad-spectrum tetracycline antibiotic used to treat various bacterial infections. It comes in two main salt forms: Doxycycline Hyclate and Doxycycline Monohydrate. Both are derived from oxytetracycline and share the same core antibacterial properties but differ in solubility, bioavailability, and specific applications.

Doxycycline Hyclate Specifications:

Purity: ≥95% (HPLC, anhydrous basis)

PH (1% solution): 2.0 - 3.0

Loss on Drying: ≤3.0%

Heavy Metals: ≤20 ppm

Assay (Anhydrous): 88.0% - 94.0% (as C₂₂H₂₄N₂O₈)

Doxycycline Monohydrate Specifications:

Purity: ≥95% (HPLC, anhydrous basis)

PH (1% solution): 2.5 - 4.5

Loss on Drying: ≤5.0%

Heavy Metals: ≤20 ppm

Assay (Anhydrous): 88.0% - 94.0% (as C₂₂H₂₄N₂O₈)

SHANDONG HIGH CHEM-PHARM CO., LTD ensures that both Doxycycline Hyclate and Monohydrate meet stringent international quality standards:

✅ GMP (Good Manufacturing Practice) Certified

✅ ISO 9001:2015 Quality Management System

✅ USP/EP/BP Compliance (United States/European/British Pharmacopoeia)

✅ CE Certification for export to European markets

✅ Animal Feed Additive Certification (for veterinary applications)

✅ Material Safety Data Sheets (MSDS) provided

All batches undergo rigorous testing for potency, purity, and safety, supported by comprehensive Certificates of Analysis (CoA).

Both forms of Doxycycline are bacteriostatic antibiotics that inhibit protein synthesis by binding to the 30S ribosomal subunit in susceptible bacteria. They are effective against a wide range of Gram-positive and Gram-negative bacteria, mycoplasma, chlamydia, and rickettsia.

Common Applications Include:

Human Medicine:

Treatment of respiratory tract infections (e.g., pneumonia, bronchitis)

Management of sexually transmitted infections (e.g., chlamydia, syphilis)

Skin and soft tissue infections (e.g., acne, cellulitis)

Malaria prophylaxis and treatment

Lyme disease treatment

Veterinary Medicine:

Treatment of respiratory infections in livestock and pets

Control of enteric infections in poultry and swine

Management of keratoconjunctivitis in cattle and goats

• Doxycycline Hyclate: Preferred for human oral formulations (tablets, capsules) due to its high solubility and consistent bioavailability. It is often used for severe infections where rapid absorption is critical.
• Doxycycline Monohydrate: Commonly used in veterinary formulations and pediatric suspensions due to its better tolerability and lower gastrointestinal irritation. It is also cost-effective for large-scale animal treatment.

• Global Export Experience: Products are exported to Europe, South America, Africa, and Asia with full regulatory support.
• Technical Support: Expert guidance on product selection, formulation, and regulatory compliance.
• Competitive Pricing: Both forms are available at competitive prices without compromising quality.